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DeCS
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Descriptor English:
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Cardiac Glycosides
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Descriptor Spanish:
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glicósidos cardíacos
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Descriptor Portuguese:
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Glicosídeos Cardíacos
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Synonyms English:
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Cardiotonic Steroids
Glycosides, Cardiac
Steroids, Cardiotonic
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Tree Number:
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D04.210.500.155.580
D09.408.180
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Definition English:
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Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose. |
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Pharmacological Action:
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Anti-Arrhythmia Agents
Cardiotonic Agents
Enzyme Inhibitors
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Allowable Qualifiers English:
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Record Number:
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2345
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Unique Identifier:
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D002301
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Occurrence in VHL:
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Similar:
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DeCS
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